LY2608204

  • CAS: 1234703-40-2
  • MDL:
  • Product number:QC-11688
  • Molecular formula: C28H37N3O3S3
  • Purity: 98.2%
  • MW: 559.81
Size Price Stock
50mg $650 in stock
100mg $995 in stock
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Brief Description

LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.
IC50 value: 42 nM (EC50)
Target: glucokinase
in vitro: LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. LY2608204 also stimulates glucose metabolism in rat insulinoma INS1-E cells with EC50 of 579 nM.
in vivo: LY2608204 decreases plasma glucose in a dose-dependent manner at both fasted and postprandial glucose levels. A maximal lowering of glucose AUC versus the untreated control group is observed with the high dose (30 mg/kg) and represents a 42% decrease. Interpolation of the data show that a 20% glucose AUC decrease occurs at an average LY2608204 concentration of 99 ng/mL (179 nM) in plasma, corresponding to a 6.9 mg/kg LY2608204 dose. The in vivo blood brain barrier permeability of LY2608204 results in a mean brain/plasma ratio of 0.17 five minutes post-dose with a mean total brain level of 0.539 nmol/g.

Solubility

DMSO 112 mg/mL Water <1 mg/mL Ethanol 35 mg/mL

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid

All CEG Chemical products are intended for laboratory research use only.

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