OSI-027

  • CAS: 936890-98-1
  • MDL:
  • Product number:QC-11756
  • Molecular formula: C21H22N6O3
  • Purity: 98.3%
  • MW: 406.44
Size Price Stock
100mg $695 in stock
250mg $1095 in stock
Inquiry

Brief Description

OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK.
IC50 value: 22/65 nM (mTORC1/2)
Target: mTORC1/mTORC2
in vitro: OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. In addition, OSI-027 inhibits mTOR signaling of phospho-4E-BP1 with an IC50 of 1 μM in cell-based assays. OSI-027 exhibits anti-proliferative activities against several acute leukemia cell lines of myeloid/megakaryocytic origin in a dose-dependent manner, including U937, KG-1, KBM-3B, ML-1, HL-60, and MEG-01 cells. A recent study shows that inhibition of mTORC1/2 by OSI-027 effectively suppresses phosphorylation of Akt (S473) and cell proliferation in breast cancer cells.
in vivo: In GEO colorectal xenograft, OSI-027 (65 mg/kg) inhibits both mTORC1 and mTORC2 effectors, including 4E-BP1, Akt, and S6 phosphorylation. Furthermore, mTORC1 and mTORC2 inhibition together by OSI-027 potently inhibits tumor growth more than mTORC1 inhibition by rapamycin.

Solubility

DMSO ≥78mg/mL; Water <1.2mg/mL; Ethanol <1.2mg/mL

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

Light yellow to yellow solid

All CEG Chemical products are intended for laboratory research use only.

Inquiry Online

Hide
  • Salutation:

  • * Country:

  • * Customer:

  • * Company Name:

  • * Email:

  • * Requested quantity:

  • Remarks:

  • Your infomation is safe with us
    *Required Fields

Products

Contact us

  • Address: No.600 Xingyuan Road, Wuxi, Jiangsu, China, 214000

  • E-mail: sales@cegchemical.com

  • Phone: +86-510-85955255

    Links