SB 203580

  • CAS: 152121-47-6
  • MDL:
  • Product number:QC-11773
  • Molecular formula: C21H16FN3OS
  • Purity: 98%
  • MW: 377.43
Size Price Stock
500mg $395 in stock
1g $595 in stock

Brief Description

SB203580(RWJ 64809) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 uM. SB203580 required to block PKB phosphorylation with ab IC50 of 3-5 uM.
IC50 Value: 0.3 -0.5 uM
Target: p38 MAPK
in vitro: SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.
in vivo: SB203580 protects pig myocardium against ischemic injury in an in vivo model. SB203580 is effective to prevent and treat the disease in MRL/lpr mice model of Systemic lupus erythematosus (SLE).


DMSO ≥72mg/mL, Water <1.2mg/mL, Ethanol ≥4.6mg/mL

Melting point

Boiling point


Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years


White to off-white solid

All CEG Chemical products are intended for laboratory research use only.

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