Pyridoclax

  • CAS: 1651890-44-6
  • MDL:
  • Product number:QC-11878
  • Molecular formula: C29H22N4
  • Purity: 99.3%
  • MW: 426.51
Size Price Stock
50mg $695 in stock
100mg $995 in stock
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Brief Description

Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.
IC50 value: 25 nM(Kd) [1]
Target: Mcl1 inhibitor
Pyridoclax is able to disrupt BimL/Mcl-1 interaction in whole living cells. Pyridoclax strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA, their combination leading to massive apoptosis. Neither ABT-737 nor Pyridoclax induced cell death as single agents, whereas their combination led to massive apoptotic cell death in both IGROV1-R10 and SKOV3 chemoresistant ovarian cancer cell lines.
References on Pyridoclax:
[1]. Gloaguen C, et al. First Evidence that Oligopyridines, Alpha Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies. J Med Chem. 2015 Jan 13.

Solubility

49 mg/ml in CHCL3

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid

All CEG Chemical products are intended for laboratory research use only.

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