ARRY-380

  • CAS: 937265-83-3
  • MDL:
  • Product number:QC-11889
  • Molecular formula: C29H27N7O4S
  • Purity: 98.8%
  • MW: 569.63
Size Price Stock
25mg $400 in stock
100mg $995 in stock
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Brief Description

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.
IC50 Value: 8 nM
ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
References on ARRY-380:
[1]. ErbB-2 inhibitor ARRY-380

Solubility

DMSO ≥110mg/mL; Water <1.2mg/mL; Ethanol <1.2mg/mL

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid

All CEG Chemical products are intended for laboratory research use only.

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