LGX818

  • CAS: 1269440-17-6
  • MDL:
  • Product number:QC-11891
  • Molecular formula: C22H27ClFN7O4S
  • Purity: 99.2%
  • MW: 540.01
Size Price Stock
10mg $395 in stock
25mg $695 in stock
50mg $995 in stock
Inquiry

Brief Description

LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
IC50 value: 0.3 nM (BRaf V600E biochemical); 2 nM (A375 cell proliferation) [1]
Target: mutated BRaf V600E
LGX818 is a drug candidate for the treatment of melanoma with the V600E mutation in the B-RAF kinase. The substance is being developed by Novartis, is in phase III clinical trials, and was disclosed at the spring 2013 American Chemical Society meeting in New Orleans. More information can be found in Patent WO2011025927A1
References on LGX818:
[1]. Compounds and compositions as protein kinase inhibitors . Patent WO 2011025927 A1
[2]. LGX818, From Wikipedia, the free encyclopedia

Solubility

in DMSO > 10 mM

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid

All CEG Chemical products are intended for laboratory research use only.

Inquiry Online

Hide
  • Salutation:

  • * Country:

  • * Customer:

  • * Company Name:

  • * Email:

  • * Requested quantity:

  • Remarks:

  • Your infomation is safe with us
    *Required Fields

Products

Contact us

  • Address: No.600 Xingyuan Road, Wuxi, Jiangsu, China, 214000

  • E-mail: sales@cegchem.com

  • Phone: +86-510-68873511

    Links